CLINICAL DOSES
BACKED BY SCIENCE
CBD STUDIES
CBD INCREASES CEREBRAL BLOOD FLOW*
Bloomfield, M. A. P., Green, S. F., Hindocha, C., Yamamori, Y., Yim, J. L. L., Jones, A. P. M., Walker, H. R., Tokarczuk, P., Statton, B., Howes, O. D., Curran, H. V., & Freeman, T. P. (2020, September). The effects of acute cannabidiol on cerebral blood flow and its relationship to memory: An arterial spin labelling magnetic resonance imaging study. Journal of psychopharmacology (Oxford, England). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7436497/
CBD HAS VASODILATORY EFFECTS*
Baranowska-Kuczko, M., Kozłowska, H., Kloza, M., Sadowska, O., Kozłowski, M., Kusaczuk, M., Kasacka, I., & Malinowska, B. (2020, May). Vasodilatory effects of cannabidiol in human pulmonary and rat small mesenteric arteries: Modification by hypertension and the potential pharmacological opportunities. Journal of hypertension. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170434/
CBD INCREASES BDNF SIGNALING*
Sales, A. J., Fogaca, M. V., Sartim, A. G., Pereira, V. S., Wegener, G., Guimaraes, F. S., & Joca, S. R. L. (2019, February). Cannabidiol induces rapid and sustained antidepressant-like effects through increased BDNF signaling and synaptogenesis in the prefrontal cortex. Molecular neurobiology. https://pubmed.ncbi.nlm.nih.gov/29869197/
CBD HAS ANTI-INFLAMMATORY EFFECTS*
Nagarkatti, P., Pandey, R., Rieder, S. A., Hegde, V. L., & Nagarkatti, M. (2009, October). Cannabinoids as novel anti-inflammatory drugs. Future medicinal chemistry. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828614/
CBD HAS NEUROPROTECTIVE EFFECTS*
di Giacomo, V., Chiavaroli, A., Recinella, L., Orlando, G., Cataldi, A., Rapino, M., Di Valerio, V., Ronci, M., Leone, S., Brunetti, L., Menghini, L., Zengin, G., Ak, G., Abdallah, H. H., & Ferrante, C. (2020, May 18). Antioxidant and neuroprotective effects induced by cannabidiol and cannabigerol in rat Ctx-TNA2 astrocytes and isolated cortexes. International journal of molecular sciences. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279038/
CBD HAS ANTIEMETIC EFFECTS*
Parker, L. A., Rock, E. M., & Limebeer, C. L. (2011, August). Regulation of nausea and vomiting by cannabinoids. British journal of pharmacology. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165951/
CBD HAS VASORELAXATION EFFECTS*
Stanley, C. P., Hind, W. H., Tufarelli, C., & O’Sullivan, S. E. (2015, September 1). Cannabidiol causes endothelium-dependent vasorelaxation of human mesenteric arteries via CB1 activation. Cardiovascular research. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540144/
CBG SAFELY LOWERS BLOOD PRESSURE*
Vernail, V. L., Bingaman, S. S., Silberman, Y., Raup-Konsavage, W. M., Vrana, K. E., & Arnold, A. C. (2022, May 9). Acute Cannabigerol administration lowers blood pressure in mice. Frontiers in physiology. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124753/
CBD HAS ANXIOLYTIC EFFECTS*
Blessing, E. M., Steenkamp, M. M., Manzanares, J., & Marmar, C. R. (2015, October). Cannabidiol as a potential treatment for anxiety disorders. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604171/
CBD INCREASES FOCUS*
Maroon, J., & Bost, J. (2018, April 26). Review of the neurological benefits of phytocannabinoids. Surgical neurology international. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938896/
CBD INCREASES BDNF LEVELS & STIMULATES NEUROGENESIS*
Calapai, G., Mannucci, C., Chinou, I., Cardia, L., Calapai, F., Sorbara, E. E., Firenzuoli, B., Ricca, V., Gensini, G. F., & Firenzuoli, F. (2019, August 29). Preclinical and clinical evidence supporting use of Cannabidiol in psychiatry. Evidence-Based Complementary and Alternative Medicine. https://www.hindawi.com/journals/ecam/2019/2509129/
INGREDIENT STUDIES
BETA-ALANINE INCREASES DOPAMINE*
Ericson, M., Clarke, R. B. C., Chau, P., Adermark, L., & Soderpalm, B. (2010, April). Beta-alanine elevates dopamine levels in the rat nucleus accumbens: Antagonism by Strychnine. Amino acids. https://pubmed.ncbi.nlm.nih.gov/19543795/
BETA-ALANINE INCREASES POWER OUTPUT AND SPEED*
Ostfeld, I., & Hoffman, J. R. (2023, February 19). The effect of β-alanine supplementation on performance, cognitive function and resiliency in soldiers. Nutrients. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961614/
BETA-ALANINE INCREASES COGNITIVE FUNCTION*
Ostfeld, I., Ben-Zeev, T., Zamir, A., Levi, C., Gepner, Y., Springer, S., & Hoffman, J. R. (2023, February). Role of β-alanine supplementation on cognitive function, mood, and physical function in older adults; double-blind randomized controlled study. Nutrients. https://pubmed.ncbi.nlm.nih.gov/36839281/
BETA-ALANINE INCREASES STRENGTH & POWER*
Hoffman, J., Ratamess, N., Kang, J., Mangine, G., Faigenbaum, A., & Stout, J. (2006, August). Effect of creatine and beta-alanine supplementation on performance and endocrine responses in strength/power athletes. International journal of sport nutrition and exercise metabolism. https://pubmed.ncbi.nlm.nih.gov/17136944/
L-TYROSINE INCREASES FOCUS & COGNITION*
Neri, D. F., Wiegmann, D., Stanny, R. R., Shappell, S. A., McCardie, A., & McKay, D. L. (1995, April). The effects of tyrosine on cognitive performance during extended wakefulness. Aviation, space, and environmental medicine. https://pubmed.ncbi.nlm.nih.gov/7794222/
L-TYROSINE INCREASES DOPAMINE AND IMPROVES COGNITION*
Bloemendaal, M., Froböse, M. I., Wegman, J., Zandbelt, B. B., van de Rest, O., Cools, R., & Aarts, E. (2018, April 30). Neuro-cognitive effects of Acute Tyrosine Administration on reactive and proactive response inhibition in healthy older adults. eNeuro. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6084775/
L-TYROSINE IMPROVES COGNITION IN STRESSFUL SITUATIONS*
Jongkees, B. K., Hommel, B., Kuhn, S., & Colzato, L. S. (2015, November). Effect of tyrosine supplementation on clinical and healthy populations under stress or cognitive demands--A review. Journal of psychiatric research. https://pubmed.ncbi.nlm.nih.gov/26424423/
LION'S MANE INCREASES NGF (NERVE GROWTH FACTOR) SYNTHESIS*
Lai, P.-L., Naidu, M., Sabaratnam, V., Wong, K.-H., David, R. P., Kuppusamy, U. R., Abdullah, N., & Malek, S. N. A. (2013). Neurotrophic properties of the Lion’s mane medicinal mushroom, hericium erinaceus (higher basidiomycetes) from Malaysia. International journal of medicinal mushrooms. https://pubmed.ncbi.nlm.nih.gov/24266378/
LION'S MANE ENHANCES NERVE REGENERATION*
Li, I.-C., Lee, L.-Y., Tzeng, T.-T., Chen, W.-P., Chen, Y.-P., Shiao, Y.-J., & Chen, C.-C. (2018, May 21). Neurohealth Properties of Hericium Erinaceus Mycelia Enriched with Erinacines. Behavioural neurology. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987239/
LION'S MANE INCREASES BDNF (BRAIN DERIVED NEUROTROPHIC FACTOR) & NGF (NERVE GROWTH FACTOR)*
Ryu, S. H., Hong, S. M., Khan, Z., Lee, S. K., Vishwanath, M., Turk, A., Yeon, S. W., Jo, Y. H., Lee, D. H., Lee, J. K., Hwang, B. Y., Jung, J.-K., Kim, S. Y., & Lee, M. K. (2021, January). Neurotrophic isoindolinones from the fruiting bodies of Hericium erinaceus. Bioorganic & medicinal chemistry letters. https://pubmed.ncbi.nlm.nih.gov/33246107/
LION'S MANE INCREASES NEUROPLASTICITY, BDNF, & NGF LEVELS AND IMPROVES MOOD*
Vigna, L., Morelli, F., Agnelli, G. M., Napolitano, F., Ratto, D., Occhinegro, A., Di Iorio, C., Savino, E., Girometta, C., Brandalise, F., & Rossi, P. (2019, April 18). Hericium Erinaceus improves mood and sleep disorders in patients affected by overweight or obesity: Could circulating Pro-BDNF and BDNF be potential biomarkers? Evidence-based complementary and alternative medicine : eCAM. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6500611/
CAFFEINE AND L-THEANINE IN COMBINATION INCREASES FOCUS AND DECREASES JITTERS*
Kelly, S. P., Gomez-Ramirez, M., Montesi, J. L., & Foxe, J. J. (2008, August). L-theanine and caffeine in combination affect human cognition as evidenced by oscillatory alpha-band activity and attention task performance. The Journal of nutrition. https://pubmed.ncbi.nlm.nih.gov/18641209/
L-THEANINE IMPROVES FOCUS AND RESILIENCE TO STRESS*
Hidese, S., Ogawa, S., Ota, M., Ishida, I., Yasukawa, Z., Ozeki, M., & Kunugi, H. (2019b, October 3). Effects of L-theanine administration on stress-related symptoms and cognitive functions in healthy adults: A randomized controlled trial. Nutrients. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836118/
ALPHA-GPC IMPROVES MOOD, COGNITIVE FUNCTION, POWER, SPEED, AND AGILITY*
Parker, A. G., Byars, A., Purpura, M., & Jäger, R. (2015, September 21). The effects of alpha-glycerylphosphorylcholine, caffeine or placebo on markers of mood, cognitive function, power, speed, and agility. Journal of the International Society of Sports Nutrition. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595381/
ALPHA-GPC HAS ERGOGENIC BENEFITS & INCREASES ACETYLCHOLINE AND DOPAMINE*
Marcus, L., Soileau, J., Judge, L. W., & Bellar, D. (2017, October 5). Evaluation of the effects of two doses of alpha glycerylphosphorylcholine on physical and psychomotor performance. Journal of the International Society of Sports Nutrition. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629791/
CHOLINE INCREASES ACETYLCHOLINE SYNTHESIS*
Penry, J. T., & Manore, M. M. (2008a, April). Choline: An important micronutrient for maximal endurance-exercise performance?. International journal of sport nutrition and exercise metabolism. https://pubmed.ncbi.nlm.nih.gov/18458362/
HUPERZINE INHIBITS ACETYLCHOLINESTERASE(AChE) & IMPROVES MEMORY*
Wang, R., Yan, H., & Tang, X. (2006, January). Progress in studies of Huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine. Acta pharmacologica Sinica. https://pubmed.ncbi.nlm.nih.gov/16364207/
HUPERZINE A IS NEUROPROTECTIVE & INCREASES SYNAPTIC PLASTICITY*
Friedli, M. J., & Inestrosa, N. C. (2021, October 29). Huperzine A and its neuroprotective molecular signaling in alzheimer’s disease. Molecules (Basel, Switzerland). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8587556/
MUCUNA PRURIENS CONTAINS L-DOPA WHICH INCREASES DOPAMINE NATURALLY*
Lampariello, L. R., Cortelazzo, A., Guerranti, R., Sticozzi, C., & Valacchi, G. (2012, October). The magic velvet bean of mucuna pruriens. Journal of traditional and complementary medicine. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942911/
MUCUNA PRURIENS IMPROVES MOOD THROUGH THE DOPAMINERGIC PATHWAY*
Rana, D. G., & Galani, V. J. (2014, January). Dopamine mediated antidepressant effect of Mucuna pruriens seeds in various experimental models of depression. Ayu. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213977/
MUCUNA PRURIENS REDUCES NEUROINFLAMMATION AND ANXIETY*
Tavares, R. L., Vasconcelos, M. H. A. de, Dutra, M. L. da V., D’Oliveira, A. B., Lima, M. D. S., Salvadori, M. G. da S. S., Pereira, R. de A., Alves, A. F., Nascimento, Y. M. do, Tavares, J. F., Guzman-Quevedo, O., & Aquino, J. de S. (2020, November 26). Mucuna pruriens administration minimizes neuroinflammation and shows anxiolytic, antidepressant and slimming effects in obese rats. Molecules (Basel, Switzerland). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730813/
Ericson, M., Clarke, R. B. C., Chau, P., Adermark, L., & Soderpalm, B. (2010, April). Beta-alanine elevates dopamine levels in the rat nucleus accumbens: Antagonism by Strychnine. Amino acids. https://pubmed.ncbi.nlm.nih.gov/19543795/
BETA-ALANINE INCREASES POWER OUTPUT AND SPEED*
Ostfeld, I., & Hoffman, J. R. (2023, February 19). The effect of β-alanine supplementation on performance, cognitive function and resiliency in soldiers. Nutrients. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961614/
BETA-ALANINE INCREASES COGNITIVE FUNCTION*
Ostfeld, I., Ben-Zeev, T., Zamir, A., Levi, C., Gepner, Y., Springer, S., & Hoffman, J. R. (2023, February). Role of β-alanine supplementation on cognitive function, mood, and physical function in older adults; double-blind randomized controlled study. Nutrients. https://pubmed.ncbi.nlm.nih.gov/36839281/
BETA-ALANINE INCREASES STRENGTH & POWER*
Hoffman, J., Ratamess, N., Kang, J., Mangine, G., Faigenbaum, A., & Stout, J. (2006, August). Effect of creatine and beta-alanine supplementation on performance and endocrine responses in strength/power athletes. International journal of sport nutrition and exercise metabolism. https://pubmed.ncbi.nlm.nih.gov/17136944/
L-TYROSINE INCREASES FOCUS & COGNITION*
Neri, D. F., Wiegmann, D., Stanny, R. R., Shappell, S. A., McCardie, A., & McKay, D. L. (1995, April). The effects of tyrosine on cognitive performance during extended wakefulness. Aviation, space, and environmental medicine. https://pubmed.ncbi.nlm.nih.gov/7794222/
L-TYROSINE INCREASES DOPAMINE AND IMPROVES COGNITION*
Bloemendaal, M., Froböse, M. I., Wegman, J., Zandbelt, B. B., van de Rest, O., Cools, R., & Aarts, E. (2018, April 30). Neuro-cognitive effects of Acute Tyrosine Administration on reactive and proactive response inhibition in healthy older adults. eNeuro. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6084775/
L-TYROSINE IMPROVES COGNITION IN STRESSFUL SITUATIONS*
Jongkees, B. K., Hommel, B., Kuhn, S., & Colzato, L. S. (2015, November). Effect of tyrosine supplementation on clinical and healthy populations under stress or cognitive demands--A review. Journal of psychiatric research. https://pubmed.ncbi.nlm.nih.gov/26424423/
LION'S MANE INCREASES NGF (NERVE GROWTH FACTOR) SYNTHESIS*
Lai, P.-L., Naidu, M., Sabaratnam, V., Wong, K.-H., David, R. P., Kuppusamy, U. R., Abdullah, N., & Malek, S. N. A. (2013). Neurotrophic properties of the Lion’s mane medicinal mushroom, hericium erinaceus (higher basidiomycetes) from Malaysia. International journal of medicinal mushrooms. https://pubmed.ncbi.nlm.nih.gov/24266378/
LION'S MANE ENHANCES NERVE REGENERATION*
Li, I.-C., Lee, L.-Y., Tzeng, T.-T., Chen, W.-P., Chen, Y.-P., Shiao, Y.-J., & Chen, C.-C. (2018, May 21). Neurohealth Properties of Hericium Erinaceus Mycelia Enriched with Erinacines. Behavioural neurology. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987239/
LION'S MANE INCREASES BDNF (BRAIN DERIVED NEUROTROPHIC FACTOR) & NGF (NERVE GROWTH FACTOR)*
Ryu, S. H., Hong, S. M., Khan, Z., Lee, S. K., Vishwanath, M., Turk, A., Yeon, S. W., Jo, Y. H., Lee, D. H., Lee, J. K., Hwang, B. Y., Jung, J.-K., Kim, S. Y., & Lee, M. K. (2021, January). Neurotrophic isoindolinones from the fruiting bodies of Hericium erinaceus. Bioorganic & medicinal chemistry letters. https://pubmed.ncbi.nlm.nih.gov/33246107/
LION'S MANE INCREASES NEUROPLASTICITY, BDNF, & NGF LEVELS AND IMPROVES MOOD*
Vigna, L., Morelli, F., Agnelli, G. M., Napolitano, F., Ratto, D., Occhinegro, A., Di Iorio, C., Savino, E., Girometta, C., Brandalise, F., & Rossi, P. (2019, April 18). Hericium Erinaceus improves mood and sleep disorders in patients affected by overweight or obesity: Could circulating Pro-BDNF and BDNF be potential biomarkers? Evidence-based complementary and alternative medicine : eCAM. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6500611/
CAFFEINE AND L-THEANINE IN COMBINATION INCREASES FOCUS AND DECREASES JITTERS*
Kelly, S. P., Gomez-Ramirez, M., Montesi, J. L., & Foxe, J. J. (2008, August). L-theanine and caffeine in combination affect human cognition as evidenced by oscillatory alpha-band activity and attention task performance. The Journal of nutrition. https://pubmed.ncbi.nlm.nih.gov/18641209/
L-THEANINE IMPROVES FOCUS AND RESILIENCE TO STRESS*
Hidese, S., Ogawa, S., Ota, M., Ishida, I., Yasukawa, Z., Ozeki, M., & Kunugi, H. (2019b, October 3). Effects of L-theanine administration on stress-related symptoms and cognitive functions in healthy adults: A randomized controlled trial. Nutrients. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836118/
ALPHA-GPC IMPROVES MOOD, COGNITIVE FUNCTION, POWER, SPEED, AND AGILITY*
Parker, A. G., Byars, A., Purpura, M., & Jäger, R. (2015, September 21). The effects of alpha-glycerylphosphorylcholine, caffeine or placebo on markers of mood, cognitive function, power, speed, and agility. Journal of the International Society of Sports Nutrition. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595381/
ALPHA-GPC HAS ERGOGENIC BENEFITS & INCREASES ACETYLCHOLINE AND DOPAMINE*
Marcus, L., Soileau, J., Judge, L. W., & Bellar, D. (2017, October 5). Evaluation of the effects of two doses of alpha glycerylphosphorylcholine on physical and psychomotor performance. Journal of the International Society of Sports Nutrition. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629791/
CHOLINE INCREASES ACETYLCHOLINE SYNTHESIS*
Penry, J. T., & Manore, M. M. (2008a, April). Choline: An important micronutrient for maximal endurance-exercise performance?. International journal of sport nutrition and exercise metabolism. https://pubmed.ncbi.nlm.nih.gov/18458362/
HUPERZINE INHIBITS ACETYLCHOLINESTERASE(AChE) & IMPROVES MEMORY*
Wang, R., Yan, H., & Tang, X. (2006, January). Progress in studies of Huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine. Acta pharmacologica Sinica. https://pubmed.ncbi.nlm.nih.gov/16364207/
HUPERZINE A IS NEUROPROTECTIVE & INCREASES SYNAPTIC PLASTICITY*
Friedli, M. J., & Inestrosa, N. C. (2021, October 29). Huperzine A and its neuroprotective molecular signaling in alzheimer’s disease. Molecules (Basel, Switzerland). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8587556/
MUCUNA PRURIENS CONTAINS L-DOPA WHICH INCREASES DOPAMINE NATURALLY*
Lampariello, L. R., Cortelazzo, A., Guerranti, R., Sticozzi, C., & Valacchi, G. (2012, October). The magic velvet bean of mucuna pruriens. Journal of traditional and complementary medicine. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942911/
MUCUNA PRURIENS IMPROVES MOOD THROUGH THE DOPAMINERGIC PATHWAY*
Rana, D. G., & Galani, V. J. (2014, January). Dopamine mediated antidepressant effect of Mucuna pruriens seeds in various experimental models of depression. Ayu. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213977/
MUCUNA PRURIENS REDUCES NEUROINFLAMMATION AND ANXIETY*
Tavares, R. L., Vasconcelos, M. H. A. de, Dutra, M. L. da V., D’Oliveira, A. B., Lima, M. D. S., Salvadori, M. G. da S. S., Pereira, R. de A., Alves, A. F., Nascimento, Y. M. do, Tavares, J. F., Guzman-Quevedo, O., & Aquino, J. de S. (2020, November 26). Mucuna pruriens administration minimizes neuroinflammation and shows anxiolytic, antidepressant and slimming effects in obese rats. Molecules (Basel, Switzerland). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730813/
NooLVL® is the same ingredient as Nitrosigine®, but with an additional 100mg of inositol. NooLVL® brings all of the clinically studied and proven benefits of Nitrosigine®.
